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Michael Kuhn: In vitro microbiomics: analyzing the effect of drugs on human gut bacteria

报告人: Doctor Michael Kuhn
讲者简介: Michael Kuhn is staff scientist in the research group of Prof. Peer Bork at the European Molecular Biology Laboratory in Heidelberg, Germany. He is working on various aspects of the microbiome, for example analyzing the response of gut bacteria to drugs in an in vitro screen. Before joining EMBL in 2016, he worked as post-doc at the BIOTEC and the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden, Germany. There, his research focused on the evolution of the centrosome, tissue-specific gene expression and the analysis of a large-scale RNAi screen. After undergraduate studies in computer science at the Caltech (Pasadena, California/USA), he obtained a PhD in the lab Peer Bork at the EMBL Heidelberg in 2009.
报告地点: Room 2403, East Main Building of Guang-Hua Tower
报告时间: 2018.9.28 14:00
报告摘要: The bacteria in our gut influence our health and well-being. Various environmental factors can change the composition of the gut flora, for example lifestyle, diseases, food and drugs. I will present the results of an in vitro screen of the effects of over 1000 drugs on 40 strains of gut bacteria. Together with the lab of Nassos Typas at the EMBL Heidelberg (Germany), we developed methods for conducting such a large-scale screen and testing for reduced growth. Verifying our findings, we found that hits in our screen cause similar changes in people taking these drugs, and that they cause more antibiotics-like side effects. We also found that bacteria that are more resistant against human-targeted drugs are also more resistant against antibiotics, pointing at the risk that even “normal” drugs can lead to antibiotics resistance.

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